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Convergent assembly of polycyclic ethers via acyl radical addition to unactivated enol ether.

Authors
  • Inoue, Masayuki
  • Ishihara, Yuuki
  • Yamashita, Shuji
  • Hirama, Masahiro
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Dec 07, 2006
Volume
8
Issue
25
Pages
5801–5804
Identifiers
PMID: 17134276
Source
Medline
License
Unknown

Abstract

A new convergent strategy for assembling 6/6- and 6/7-fused ether ring systems was developed. The key features in our method include Ag+-promoted facile formation of chemically labile enol ether from O,S-acetal and addition of an acyl radical to unactivated enol ether to cyclize a six- or seven-membered ether ring. [reaction: see text]

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