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Convergent antibody signatures in human dengue.

Authors
  • P, Parameswaran
  • Y, Liu
  • Km, Roskin
  • Kk, Jackson
  • Vp, Dixit
  • Jy, Lee
  • Kl, Artiles
  • S, Zompi
  • Mj, Vargas
  • Bb, Simen
  • B, Hanczaruk
  • Kr, Mcgowan
  • Ma, Tariq
  • Nader Pourmand
  • D, Koller
  • A, Balmaseda
  • Sd, Boyd
  • E, Harris
  • Az, Fire
Type
Published Article
Journal
Cell Host & Microbe
Publisher
Elsevier
Volume
13
Issue
6
Pages
691–700
Identifiers
DOI: 10.1016/j.chom.2013.05.008
Source
UCSC Nanotech biomedical-ucsc
License
Unknown

Abstract

Dengue is the most prevalent mosquito-borne viral disease in humans, and the lack of early prognostics, vaccines, and therapeutics contributes to immense disease burden. To identify patterns that could be used for sequence-based monitoring of the antibody response to dengue, we examined antibody heavy-chain gene rearrangements in longitudinal peripheral blood samples from 60 dengue patients. Comparing signatures between acute dengue, postrecovery, and healthy samples, we found increased expansion of B cell clones in acute dengue patients, with higher overall clonality in secondary infection. Additionally, we observed consistent antibody sequence features in acute dengue in the highly variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specific CDR3 sequences highly enriched in acute samples compared to postrecovery, healthy, or non-dengue samples. Dengue thus provides a striking example of a human viral infection where convergent immune signatures can be identified in multiple individuals. Such signatures could facilitate surveillance of immunological memory in communities.

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