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Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging.

Authors
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
Volume
98
Issue
3
Pages
584–590
Identifiers
PMID: 12650432
Source
Medline
License
Unknown

Abstract

Distribution of a macromolecule to clinically significant volumes in the brain is possible using convection. The spatial dimensions of the tissue distribution can be accurately defined in vivo during infusion by using surrogate tracers and conventional imaging techniques, and it is expected that it will be possible to determine local concentrations of surrogate tracers in voxels of tissue in vivo by using CT scanning. Use of imaging surrogate tracers is a practical, safe, and essential tool for establishing treatment volumes during high-flow interstitial microinfusion of the central nervous system.

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