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Controlling fibroblast adhesion and proliferation by 1D Al2O3 nanostructures.

Authors
  • Aktas, Oral Cenk1
  • Metzger, Wolfgang2
  • Mees, Lisa2
  • Martinez, Marina Miro3
  • Haidar, Ayman4
  • Oberringer, Martin2
  • Wennemuth, Gunther5
  • Pütz, Norbert6
  • Ghori, Muhammad Zubair7
  • Pohlemann, Tim2
  • Veith, Michael3
  • 1 Department of Paediatric Cardiology, Saarland University, 66421 Homburg, Germany. [email protected]. , (Germany)
  • 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany. , (Germany)
  • 3 INM-Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany. , (Germany)
  • 4 Department of Paediatric Cardiology, Saarland University, 66421 Homburg, Germany. , (Germany)
  • 5 University Clinic Essen, Department of Anatomy, 45147 Essen, Germany. , (Germany)
  • 6 Department of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany. , (Germany)
  • 7 Institute for Materials Science, Christian-Albrechts-University of Kiel, 24143 Kiel, Germany. , (Germany)
Type
Published Article
Journal
IET nanobiotechnology
Publication Date
Aug 01, 2019
Volume
13
Issue
6
Pages
621–625
Identifiers
DOI: 10.1049/iet-nbt.2018.5088
PMID: 31432796
Source
Medline
Language
English
License
Unknown

Abstract

The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast-surface interaction. In the present study, one-dimensional aluminium oxide (1D Al2O3) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well-defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al2O3 nanostructures on the substratum.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 02/14/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31432796
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