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Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/pva hydrogel composites for implantable devices.

Authors
  • Bhardwaj, Upkar1
  • Sura, Radhakrishna
  • Papadimitrakopoulos, Fotios
  • Burgess, Diane J
  • 1 School of Pharmacy, University of Connecticut, Storrs, CT, USA.
Type
Published Article
Journal
Journal of Diabetes Science and Technology
Publisher
SAGE Publications
Publication Date
January 2007
Volume
1
Issue
1
Pages
8–17
Identifiers
PMID: 19888374
Source
Medline
Keywords
License
Unknown

Abstract

Fast release of dexamethasone from PLGA/PVA composites did not provide long-term protection against the foreign body reaction in response to implantation. It would appear that a sustained delivery of anti-inflammatory agents such as dexamethasone is necessary to suppress inflammation throughout the implant life-time.

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