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A controlled trial of amitriptyline and cianopramine in major depression.

Authors
  • Mellsop, G W
  • Burgess, C D
  • Vijayasenan, M E
Type
Published Article
Journal
Clinical Therapeutics
Publisher
Elsevier
Publication Date
Jan 01, 1985
Volume
7
Issue
6
Pages
699–703
Identifiers
PMID: 3907842
Source
Medline
License
Unknown

Abstract

The therapeutic efficacy and adverse effects of amitriptyline and cianopramine were compared in a double-blind, randomized, flexible-dose trial in 40 patients with major depressive episodes. The two drugs were equally effective in reducing scores on the Hamilton Psychiatric Rating Scale for Depression and on a global scale. Both drugs were associated with significant adverse effects. Fewer adverse effects were associated with cianopramine, however, which lacks antimuscarinic activity.

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