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Controlled release of multi-component cytotoxic agents from radiation polymerized composites.

Authors
  • Kaetsu, I
  • Yoshida, M
  • Kumakura, M
  • Yamada, A
  • Sakurai, Y
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Jan 01, 1980
Volume
1
Issue
1
Pages
17–22
Identifiers
PMID: 7470547
Source
Medline
Language
English
License
Unknown

Abstract

Multi-component cytotoxic (anticancer) agents such as mitomycin C (MMC), adryamycin (ADM) and 1-(2-tetrahydrofuryl-5-fluorouracil) (FT-207), were entrapped in a single common composite by radiation-induced polymerization of glass-forming monomers in the presence of polymers. The release profiles of each cytotoxic agent were controlled by the contents and compositions of three cytotoxic agents in the matrix. The release rates of each cytotoxic agent were retarded by addition of an adsorbent and accelerated by addition of a pore-making agent. The release fom the common matrix of a cytotoxic agent and its promoter which have markedly different molecular weights [e.g. MMC and urokinase (UK)] was also investigated. A double entrapping method was successfully used for controlled release in such cases. In conclusion it was found that the release profiles of multi-components in a single matrix could be controlled by using these techniques.

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