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Controlled fabrication of multi-core alginate microcapsules.

Authors
  • Eqbal, Md Danish1
  • Gundabala, Venkat2
  • 1 Department of Chemical Engineering, Indian Institute of Technology (IIT) Bombay, Powai, Mumbai 400076, India. , (India)
  • 2 Department of Chemical Engineering, Indian Institute of Technology (IIT) Bombay, Powai, Mumbai 400076, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
Journal of Colloid and Interface Science
Publisher
Elsevier
Publication Date
Dec 01, 2017
Volume
507
Pages
27–34
Identifiers
DOI: 10.1016/j.jcis.2017.07.100
PMID: 28780332
Source
Medline
Keywords
License
Unknown

Abstract

In this work, we present a robust microfluidic platform for controlled and complete on-chip generation of alginate microcapsules with single and double liquid cores. A combined Coflow and T-junction configuration implemented in a hybrid glass-PDMS (Polydimethylsiloxane) device is used for the generation of microcapsules with oil as liquid core. Frequency matching of oil-alginate double emulsion generation with that of aqueous Calcium chloride droplet generation allows for controlled merging of the two, resulting in reliable production of microcapsules. Confocal imaging of microcapsule cross-section reveals presence of intact liquid core. In the case of double core microcapsules, the two cores are well separated by alginate layer ensuring their long term stability. The current approach is expected to have advantages over existing techniques for liquid core microcapsule generation in terms of continuity of the process, control over core stability, and non-damage to cells when used for cell encapsulation applications.

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