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Control of synapse number by glia.

Authors
  • Ullian, E M
  • Sapperstein, S K
  • Christopherson, K S
  • Barres, B A
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jan 26, 2001
Volume
291
Issue
5504
Pages
657–661
Identifiers
PMID: 11158678
Source
Medline
License
Unknown

Abstract

Although astrocytes constitute nearly half of the cells in our brain, their function is a long-standing neurobiological mystery. Here we show by quantal analyses, FM1-43 imaging, immunostaining, and electron microscopy that few synapses form in the absence of glial cells and that the few synapses that do form are functionally immature. Astrocytes increase the number of mature, functional synapses on central nervous system (CNS) neurons by sevenfold and are required for synaptic maintenance in vitro. We also show that most synapses are generated concurrently with the development of glia in vivo. These data demonstrate a previously unknown function for glia in inducing and stabilizing CNS synapses, show that CNS synapse number can be profoundly regulated by nonneuronal signals, and raise the possibility that glia may actively participate in synaptic plasticity.

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