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Control of osteoblast function and regulation of bone mass.

Authors
  • Harada, Shun-ichi
  • Rodan, Gideon A
Type
Published Article
Journal
Nature
Publication Date
May 15, 2003
Volume
423
Issue
6937
Pages
349–355
Identifiers
PMID: 12748654
Source
Medline
License
Unknown

Abstract

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

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