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[Control by major histocompatibility complex genes of macrophage interaction with thymocytes during induction of T-effectors of graft vs host reaction. I. Genetic control on the cellular level].

Authors
  • Galaktionov, V G
  • Anfalova, T V
  • Lutsan, N I
  • Golenishchev, V Iu
  • Poznakhirev, P R
Type
Published Article
Journal
Genetika
Publication Date
Feb 01, 1986
Volume
22
Issue
2
Pages
244–252
Identifiers
PMID: 2937686
Source
Medline
License
Unknown

Abstract

H-2 complex control of interaction between macrophages and thymocytes during induction of T-cell effectors GVH was studied. Intensity of the local GVH reaction was evaluated by the index of the lymph nodes enlargement. Genes of the H-2 system control interaction of macrophages with thymocytes during the formation of T-cell effectors GVH. H-2K subregion genes identity of interacting cells was necessary and sufficient for the effective induction of T-effectors GVH. I and D region differences did not affect the formation of T-cells inducing GVH.

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