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"Control" laboratory rodents are metabolically morbid: why it matters.

Authors
  • Martin, Bronwen1
  • Ji, Sunggoan
  • Maudsley, Stuart
  • Mattson, Mark P
  • 1 Metabolism Unit, Laboratory of Clinical Investigation, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Apr 06, 2010
Volume
107
Issue
14
Pages
6127–6133
Identifiers
DOI: 10.1073/pnas.0912955107
PMID: 20194732
Source
Medline
License
Unknown

Abstract

Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.

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