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CONTROL OF ENZYME ACTIVITY IN GROWING BACTERIAL CELLS BY CONCERTED FEEDBACK INHIBITION.

Authors
  • BURLANT, L
  • DATTA, P
  • GEST, H
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Jun 04, 1965
Volume
148
Issue
3675
Pages
1351–1353
Identifiers
PMID: 14281723
Source
Medline
Keywords
License
Unknown

Abstract

Amino acids of the aspartic acid family are synthesized in bacteria through a multistep branched pathway. In the photosynthetic bacterium Rhodopseudomonas capsulatus, the enzyme that catalyzes the first step is specifically inhibited by a combination of two end-product amino acids. Evidence is presented for operation of this kind of "concerted" feedback control as a regulatory device in growing cells.

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