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Control of B lymphocyte apoptosis by the transcription factor NF-kappaB.

Authors
  • Sen, Ranjan1
  • 1 Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, Maryland 21224, USA. [email protected]
Type
Published Article
Journal
Immunity
Publisher
Elsevier
Publication Date
Dec 01, 2006
Volume
25
Issue
6
Pages
871–883
Identifiers
PMID: 17174931
Source
Medline
License
Unknown

Abstract

B cells maintain homeostasis by balancing cell viability and cell death. B lymphocytes are susceptible to mitochondria- and receptor-initiated cell death at various stages of peripheral differentiation and during immune responses. The inducible transcription factor NF-kappaB enhances cell viability by activating genes that counteract both cell-death pathways. This review uses characteristic features of NF-kappaB activation and downregulation to provide insight into the regulation of B cell apoptosis in the periphery. In particular, the temporal patterns of NF-kappaB induction, differences between Rel family members, and the intersection between canonical and noncanonical signaling pathways in keeping B cells alive are discussed.

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