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Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia.

Authors
  • Haut, Kristen M1
  • van Erp, Theo G M2
  • Knowlton, Barbara3
  • Bearden, Carrie E4
  • Subotnik, Kenneth5
  • Ventura, Joseph5
  • Nuechterlein, Keith H4
  • Cannon, Tyrone D6
  • 1 Department of Psychology, Yale University.
  • 2 Department of Psychiatry and Human Behavior, University of California, Irvine.
  • 3 Department of Psychology, University of California, Los Angeles.
  • 4 Department of Psychology, University of California, Los Angeles ; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
  • 5 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
  • 6 Department of Psychology, Yale University ; Department of Psychiatry, Yale University.
Type
Published Article
Journal
Clinical psychological science : a journal of the Association for Psychological Science
Publication Date
Mar 01, 2015
Volume
3
Issue
2
Pages
159–174
Identifiers
PMID: 25750836
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Patients with and at risk for psychosis may have difficulty using associative strategies to facilitate episodic memory encoding and recall. In parallel studies, patients with first-episode schizophrenia (n = 27) and high psychosis risk (n = 28) compared with control participants (n = 22 and n = 20, respectively) underwent functional MRI during a remember-know memory task. Psychophysiological interaction analyses, using medial temporal lobe (MTL) structures as regions of interest, were conducted to measure functional connectivity patterns supporting successful episodic memory. During encoding, patients with first-episode schizophrenia demonstrated reduced functional coupling between MTL regions and regions involved in stimulus representations, stimulus selection, and cognitive control. Relative to control participants and patients with high psychosis risk who did not convert to psychosis, patients with high psychosis risk who later converted to psychosis also demonstrated reduced connectivity between MTL regions and auditory-verbal and visual-association regions. These results suggest that episodic memory deficits in schizophrenia are related to inefficient recruitment of cortical connections involved in associative memory formation; such deficits precede the onset of psychosis among those individuals at high clinical risk.

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