The kinetics of binucleate cells, formed by the action of deoxyguanosine, are studied using three methods: in a population synchronized with hydroxyurea, by autoradiography after pulse-labelling, and in a sample of a cell population morphologically located at the M--G1 limit. Deoxyguanosine induces a slowing down in S and G2, independent of the inhibition of cytokinesis. It is only when it takes effect during the G2 stage that deoxyguanosine brings about the formation of binucleate cells.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/363267