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Contribution of platelets to tumour metastasis.

Authors
Type
Published Article
Journal
Nat Rev Cancer
1474-175X
Publication Date
Volume
11
Issue
2
Pages
123–134
Identifiers
DOI: 10.1038/nrc3004
PMID: 21258396
Source
Medline
License
Unknown

Abstract

Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.

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