Affordable Access

deepdyve-link
Publisher Website

Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan.

Authors
  • Hsu, Shih-Wei1, 2, 3
  • Gong, Chi-Li4
  • Hsu, Huai-Mei1, 5
  • Chao, Chih-Chang6
  • Wang, Yun-Chi5
  • Chang, Wen-Shin5
  • Tsai, Yueh-Ting5
  • Shih, Liang-Chun1, 7
  • Tsai, Chia-Wen5
  • Bau, DA-Tian8, 5, 9
  • 1 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. , (China)
  • 2 Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C. , (Taiwan)
  • 3 National Defense Medical Center, Taipei, Taiwan, R.O.C. , (Taiwan)
  • 4 Department of Physiology, China Medical University, Taichung, Taiwan, R.O.C. , (China)
  • 5 Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C. , (China)
  • 6 Institute of Neurosciences, National Chengchi University, Taipei, Taiwan, R.O.C. , (Taiwan)
  • 7 Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C. , (China)
  • 8 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. [email protected] [email protected] , (China)
  • 9 Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. , (Taiwan)
Type
Published Article
Journal
Cancer Genomics & Proteomics
Publisher
International Institute of Anticancer Research
Publication Date
Jan 01, 2019
Volume
16
Issue
4
Pages
287–292
Identifiers
DOI: 10.21873/cgp.20133
PMID: 31243109
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Report this publication

Statistics

Seen <100 times