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Contribution of Extra-Cardiac Cells in Murine Heart Valves is Age-Dependent.

Authors
  • Anstine, Lindsey J1, 2, 3
  • Horne, Tori E2, 3
  • Horwitz, Edwin M4, 5, 6
  • Lincoln, Joy7, 2, 3
  • 1 Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH.
  • 2 Center for Cardiovascular Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
  • 3 The Heart Center, Nationwide Children's Hospital, Columbus, OH.
  • 4 Department of Pediatrics, The Ohio State University, Columbus, OH.
  • 5 Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
  • 6 Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH.
  • 7 Department of Pediatrics, The Ohio State University, Columbus, OH [email protected]
Type
Published Article
Journal
Journal of the American Heart Association
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 20, 2017
Volume
6
Issue
10
Identifiers
DOI: 10.1161/JAHA.117.007097
PMID: 29054843
Source
Medline
Keywords
License
Unknown

Abstract

Findings from this study demonstrate that the percentage of CD45-positive extracardiac cells reside within endothelial and interstitial regions of heart valve structures increases with age. In addition, bone transplantation studies show that engraftment is dependent on the age of the donor and age of the tissue environment of the recipient. These studies create a foundation for further work defining the role of extracardiac cells in homeostatic and diseased heart valves.

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