This paper, which is largely based on the findings of my doctoral study, investigated the contribution of effective library and information services to academic achievements at universities in Ghana. The main objective of this study was to assess and explore the effectiveness of library and information services and establish its contribution to efficient academic work. The researchers adopted a mixed methods approach in which both qualitative and quantitative research approaches are used in a single study. This study used a survey research design because of the large and wide-spread population involved. The results of the study established that there is a correlation between effective library and information services and academic achievements at the universities in Ghana. The study also establish that library users were generally satisfied with the services provided by the university libraries and the provision of study space, book lending and Internet services turn out to be the most effective and highly patronized services. The findings on the challenges facing the delivery of effective library and information services clearly indicate that inadequate staff training programmes were affecting the ability of library staff to deliver effective library services. Finally, this paper has made recommendations on how to improve upon the effectiveness of library and information services to enhance academic work at universities in Ghana.