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Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors.

Authors
  • Chen, Wei-Chih1
  • Hu, Gangqing2
  • Hazlehurst, Lori A3
  • 1 Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506 USA; Cancer Institute, West Virginia University, Morgantown, WV 26506 USA.
  • 2 Cancer Institute, West Virginia University, Morgantown, WV 26506 USA; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506 USA.
  • 3 Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506 USA; Cancer Institute, West Virginia University, Morgantown, WV 26506 USA. Electronic address: [email protected]
Type
Published Article
Journal
Current opinion in pharmacology
Publication Date
Sep 05, 2020
Volume
54
Pages
36–43
Identifiers
DOI: 10.1016/j.coph.2020.08.006
PMID: 32898723
Source
Medline
Language
English
License
Unknown

Abstract

The bone marrow microenvironment (BMM) provides input via production of cytokines, chemokines, extracellular matrixes in the context of lower oxygen levels that influences self-renewal, survival, differentiation, progression, and therapeutic resistance of multiple myeloma and leukemic cells. Within the context of the BMM, tumor cells are supported by osteoblasts, bone marrow stromal cells (BMSCs), fibroblasts, myeloid cells, endothelial cells and blood vessels, as well as extracellular matrix (ECM) that contribute to tumor progression. Environmental mediated-drug resistance (EM-DR) contains cell adhesion-mediated drug resistance (CAM-DR) and soluble factor-mediated drug resistance (SM-DR) that contributes to de novo drug resistance. In this review, we focus on the crosstalk between the BMM and tumor cells as well as mechanisms underlying the BMM contributing to drug resistance in hematologic malignancies. Copyright © 2020 Elsevier Ltd. All rights reserved.

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