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Contradictory responses in induction of delayed type hypersensitivity in orally immunized mice.

Authors
  • Tsuru, S
  • Fujisawa, H
  • Aiso, S
  • Zinnaka, Y
  • Nomoto, K
Type
Published Article
Journal
Journal of clinical & laboratory immunology
Publication Date
Jun 01, 1987
Volume
23
Issue
2
Pages
91–94
Identifiers
PMID: 2442393
Source
Medline
License
Unknown

Abstract

Induction of delayed type hypersensitivity (DTH) in mice fed with sheep red blood cells (SRBC) and live Vibrio cholerae (V. cholerae) both forcedly and ad lib was comparatively investigated. Although suppression of DTH to SRBC or V. cholerae was induced in mice fed forcedly for 1 or 2 weeks, mice fed ad lib could produce the positive footpad reactions to antigens. Furthermore, the suppression of DTH in forcedly fed mice showed an antigenic specificity. These observations indicated that the induction of unresponsiveness to DTH in orally immunized mice was markedly influenced by the oral administration.

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