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Continuous subcutaneous instillation of bupivacaine compared to saline reduces interleukin 10 and increases substance P in surgical wounds after cesarean delivery.

Authors
  • 1
  • 1 Department of Anesthesia, H3580, Stanford University School of Medicine, Stanford, CA 94305, USA. [email protected]
Type
Published Article
Journal
Anesthesia and analgesia
1526-7598
Publication Date
Volume
111
Issue
6
Pages
1452–1459
Identifiers
DOI: 10.1213/ANE.0b013e3181f579de
PMID: 20861424
Source
Medline
License
Unknown

Abstract

This study demonstrates that the continuous administration of clinically used doses of bupivacaine into wounds affects the local composition of wound mediators. Observed changes in interleukin 10 are compatible with a disruption of antiinflammatory mechanisms. Whether such modulation combined with the release of the proinflammatory mediator substance P results in an overall proinflammatory wound response will require future studies of wound healing.

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