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Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout a 12-week treatment with timolol maleate in rabbits.

Authors
  • Akaishi, Takahiro
  • Ishida, Naruhiro
  • Shimazaki, Atsushi
  • Hara, Hideaki
  • Kuwayama, Yasuaki
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Dec 01, 2005
Volume
21
Issue
6
Pages
436–444
Identifiers
PMID: 16386085
Source
Medline
License
Unknown

Abstract

TM-gel administered once-daily was as effective at lowering IOP as TM administrated twice-daily over the 12-week experimental period. This study reveals that, in rabbits, both formulations of the timolol maleate induced significant IOP reductions in the dark phase and decreased the amplitudes of the circadian fluctuations in IOP for 12 successive weeks.

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