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Continuous Glucose Monitoring in the Management of Neonates with Persistent Hypoglycaemia and Congenital Hyperinsulinism.

  • Win, Myat1
  • Beckett, Rowan2
  • Thomson, Lynn1
  • Thankamony, Ajay1, 2
  • Beardsall, Kathy1, 2
  • 1 Cambridge University Hospitals NHS Trust, Cambridge Biomedical Campus, Hills Road, Cambridge.
  • 2 University of Cambridge, Clinical school of Medicine, Cambridge Biomedical Campus, Hills Road, Cambridge.
Published Article
The Journal of Clinical Endocrinology & Metabolism
The Endocrine Society
Publication Date
Aug 18, 2021
DOI: 10.1210/clinem/dgab601
PMID: 34407200


Persistent hypoglycaemia is common in the newborn and is associated with poor neurodevelopmental outcome. Adequate monitoring is critical in prevention, but is dependent on frequent, often hourly blood sampling. Continuous glucose monitoring (CGM) is increasingly being used in children with type 1 diabetes mellitus, but use in neonatology remains limited. We aimed to introduce real-time CGM to provide insights into patterns of dysglycaemia and to support the management of persistent neonatal hypoglycaemia. This is a single centre retrospective study of real-time CGM use over a 4-year period in babies with persistent hypoglycaemia. CGMs were inserted in 14 babies: 8 term and 6 preterm infants, 9 with evidence of congenital hyperinsulinism (CHI). A total of 224 days of data were collected demonstrating marked fluctuations in glucose levels in babies with CHI, with a higher sensor glucose SD (1.52±0.79 mmol/l vs 0.77±0.22mmol/l) in infants with CHI compared to preterm infants. A total of 1254 paired glucose values (CGM and blood) were compared and gave a mean absolute relative difference (MARD) of 11%. CGM highlighted the challenges of preventing hypoglycaemia in these babies when using intermittent blood glucose levels alone, and the potential application of CGM as an adjunct to clinical care. © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected]

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