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Continuous body fluid monitoring for zomepirac by fully automated high-performance liquid chromatography.

Authors
  • Müller, H
  • Zulliger, H W
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 1985
Volume
35
Issue
1
Pages
152–154
Identifiers
PMID: 4039145
Source
Medline
License
Unknown

Abstract

A sensitive, specific and rapid determination of 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid sodium salt dihydrate (zomepirac sodium, Zomax) in human plasma and urine by a continuous body fluid monitoring system based on high-performance liquid chromatography is described. Samples are directly injected into the apparatus which consists of commonly available HPLC-modules. Manual sample clean-up procedures as well as the addition of an internal standard are not needed. Using 50-microliter aliquots, the detection limit is lower than 0.05 microgram/ml and the calibration ranges from 0.5 to 100 micrograms/ml are linear for both, spiked samples and references. The recovery is 97% for plasma and 95% for urine samples at a sampling rate of about 15 samples/h.

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