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Continued use of trastuzumab beyond disease progression in the national comprehensive cancer network: should we practice ahead of the evidence?

Authors
  • Wong, Yu-Ning
  • Ottesen, Rebecca A
  • Hughes, Melissa E
  • Niland, Joyce C
  • Theriault, Richard
  • Edge, Stephen B
  • Blayney, Douglas
  • Weeks, Jane C
Type
Published Article
Journal
The Oncologist
Publisher
Alphamed Press
Publication Date
Jan 01, 2011
Volume
16
Issue
5
Pages
559–565
Identifiers
DOI: 10.1634/theoncologist.2010-0360
PMID: 21450786
Source
Medline
License
Unknown

Abstract

Prior to the availability of any high-quality evidence supporting this practice, over three quarters of patients treated with trastuzumab for HER-2+ metastatic breast cancer at eight NCCN centers continued therapy beyond progression. Further work is needed to understand how physicians adopt new treatments when there is ambiguity surrounding their benefit.

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