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Contingent negative variation: methods and potential interest in headache.

Authors
  • Schoenen, J
  • Timsit-Berthier, M
Type
Published Article
Journal
Cephalalgia : an international journal of headache
Publication Date
Feb 01, 1993
Volume
13
Issue
1
Pages
28–32
Identifiers
PMID: 8448784
Source
Medline
License
Unknown

Abstract

Contingent negative variation (CNV) is an event-related slow cerebral potential which has been found abnormal in migraine. Its methodology is described. Contrary to other neurophysiological techniques, CNV needs special equipment and expertise. On average, CNV amplitude is increased and its habituation is lacking in migraine without aura between attacks, but not in migraine with aura. The sensitivity of CNV as a diagnostic tool is low, but its specificity is high. CNV amplitude normalizes after treatment with beta-blockers. The CNV abnormalities in migraine might be due to hyperreactivity of central catecholaminergic pathways.

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