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Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Authors
  • Jimenez, Jessica C.1, 2
  • Berry, Jack E.1, 2
  • Lim, Sean C.1, 2
  • Ong, Samantha K.1, 2
  • Kheirbek, Mazen A.3, 4
  • Hen, Rene1, 2
  • 1 Columbia University, New York, NY, USA , New York (United States)
  • 2 New York State Psychiatric Institute, New York, NY, USA , New York (United States)
  • 3 Center for Integrative Neuroscience, San Franciso, CA, USA , San Franciso (United States)
  • 4 University of California, San Francisco, CA, USA , San Francisco (United States)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Jul 13, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-17270-w
Source
Springer Nature
License
Green

Abstract

The vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is proportional to memory strength and requires the shock response during encoding.

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