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Construction and Validation of a Multi-Institutional Tissue Microarray of Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations.

Authors
  • Seijo, Edward1
  • Lima, Diana
  • Iriabho, Egiebade
  • Almeida, Jonas
  • Monico, Jesus
  • Echeverri, Margarita
  • Gutierrez, Sylvia
  • Flores, Idhaliz
  • Lee, Ji-Hyun
  • Fisher, Kate
  • Grizzle, William E
  • Sica, Gabriel L
  • Butler, Charles
  • Hicks, Chindo
  • Meade, Cathy D
  • Sodeke, Stephen Olufemi
  • Moroz, Krzysztof
  • Coppola, Domenico
  • Munoz-Antonia, Teresita
Type
Published Article
Journal
Cancer control : journal of the Moffitt Cancer Center
Publication Date
Oct 01, 2016
Volume
23
Issue
4
Pages
383–389
Identifiers
PMID: 27842327
Source
Medline
Language
English
License
Unknown

Abstract

The scarcity of tissues from racial and ethnic minorities at biobanks poses a scientific constraint to research addressing health disparities in minority populations. To address this gap, the Minority Biospecimen/Biobanking Geographic Management Program for region 3 (BMaP-3) established a working infrastructure for a "biobanking" hub in the southeastern United States and Puerto Rico. Herein we describe the steps taken to build this infrastructure, evaluate the feasibility of collecting formalin-fixed, paraffin-embedded tissue blocks and associated data from a single cancer type (breast), and create a web-based database and tissue microarrays (TMAs). Cancer registry data from 6 partner institutions were collected, representing 12,408 entries from 8,279 unique patients with breast cancer (years 2001-2011). Data were harmonized and merged, and deidentified information was made available online. A TMA was constructed from formalin-fixed, paraffin-embedded samples of invasive ductal carcinoma (IDC) representing 427 patients with breast cancer (147 African Americans, 168 Hispanics, and 112 non-Hispanic whites) and was annotated according to biomarker status and race/ethnicity. Biomarker analysis of the TMA was consistent with the literature. Contributions from participating institutions have facilitated a robust research tool. TMAs of IDC have now been released for 5 projects at 5 different institutions.

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