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[Construction of glucosylceramide synthase-specific siRNA expression vector and its efficiency in reversal of drug resistance in breast carcinoma cells].

Authors
  • Sun, Yan-lin
  • Zhou, Geng-yin
  • Li, Kai-nan
  • Li, Wen-tong
  • Song, Xian-rang
  • Gao, Peng
Type
Published Article
Journal
Zhonghua yi xue za zhi
Publication Date
Mar 02, 2005
Volume
85
Issue
8
Pages
518–521
Identifiers
PMID: 15949329
Source
Medline
License
Unknown

Abstract

A GCS-specific small interfering RNA expression vector has been constructed successfully that suppresses the GCS expression and reverses the multidrug resistance in breast carcinoma cells by increasing the ratio of apoptosis in drug-resistant cells.

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