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Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.

Authors
  • Jarjour, W
  • Mizzen, L A
  • Welch, W J
  • Denning, S
  • Shaw, M
  • Mimura, T
  • Haynes, B F
  • Winfield, J B
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Dec 01, 1990
Volume
172
Issue
6
Pages
1857–1860
Identifiers
PMID: 1979591
Source
Medline
License
Unknown

Abstract

Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors. This anti-hsp58-reactive antigen is not demonstrable on T cells that express alpha/beta receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface of gamma/delta T cells is a approximately 77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEL-related stress proteins and gamma/delta cells that recognize groEL homologous in immunologic defense against infection and in autoimmune disease.

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