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A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.

Authors
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Volume
310
Issue
5754
Pages
1683–1686
Source
UCSC Aging biomedical-ucsc
License
Unknown

Abstract

We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.

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