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Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Authors
Type
Published Article
Journal
Journal of Virology
1098-5514
Publisher
American Society for Microbiology
Publication Date
Volume
86
Issue
18
Pages
10194–10199
Identifiers
DOI: 10.1128/JVI.01249-12
PMID: 22740405
Source
Medline
License
Unknown

Abstract

The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.

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