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Consequences of coronavirus disease-2019 (COVID-19) lockdown on infection-related hospitalizations among the pediatric population in Denmark

Authors
  • Polcwiartek, Laura Bech1
  • Polcwiartek, Christoffer1
  • Andersen, Mikkel Porsborg2
  • Østergaard, Lauge3
  • Broccia, Marcella D.2, 1
  • Gislason, Gunnar H.4, 5
  • Køber, Lars3
  • Torp-Pedersen, Christian1, 2
  • Schou, Morten5
  • Fosbøl, Emil3
  • Kragholm, Kristian1, 6, 1
  • Hagstrøm, Søren1, 7, 8
  • 1 Aalborg University Hospital,
  • 2 Nordsjaellands Hospital,
  • 3 Rigshospitalet,
  • 4 The Danish Heart Foundation,
  • 5 Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark
  • 6 Department of Cardiology, North Denmark Regional Hospital, Bispensgade 37, 9800 Hjørring, Denmark
  • 7 Center for Clinical Research, North Denmark Regional Hospital, Bispensgade 37, 9800 Hjørring, Denmark
  • 8 Aalborg University,
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
Feb 08, 2021
Pages
1–9
Identifiers
DOI: 10.1007/s00431-021-03934-2
PMID: 33555426
PMCID: PMC7868522
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

It remains unknown how Coronavirus disease-2019 (COVID-19) prevention measures implemented on March 12, 2020, have affected the rate of pediatric infection-related hospitalizations in Denmark. Therefore, we investigated the rate of pediatric infection–related hospitalizations during the COVID-19 pandemic. We used a retrospective cohort design and included all Danish children < 18 years. Infection-related hospitalizations were assessed during study periods in 2020 vs. 2018/2019, and we computed incidence rate ratios (IRRs) with 95% confidence intervals (CIs) using Poisson regression. In the 2020 study period, 3093 children were hospitalized with an infection, while the corresponding figures for 2018 and 2019 study periods were 4824 and 3830, respectively. When comparing the 2020 to the 2018/2019 study period prior to nationwide lockdown, we observed a decline in infection-related hospitalizations (12.68 (95% CI, 12.22–13.16) vs. 15.49 (95% CI, 15.12–15.86) per 1000 person-years). We further observed decreased IRRs, especially during the lockdown period (week 11: 0.64 (95% CI, 0.55–0.75); week 12: 0.26 (95% CI, 0.21–0.33); week 13: 0.13 (95% CI, 0.10–0.19)). Conclusion : The rate of pediatric infection-related hospitalizations in Denmark declined during the COVID-19 pandemic in 2020 compared to that in 2018/2019, with a 36% decline during initiation of the nationwide lockdown period. What is Known: • Due to the COVID-19 pandemic, several countries have implemented mitigation strategies such as lockdown of non-critical business functions. Most of these strategies have previously been proven effective on interruption of infection transmission. • It remains unclear how the mitigation strategies have affected the rate of pediatric infection–related hospitalizations. What is New: • Insight on how COVID-19 prevention measures have affected the frequency of infection-related hospitalization. • Valuable knowledge on how to act in potential future pandemics. Supplementary Information The online version contains supplementary material available at 10.1007/s00431-021-03934-2.

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