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A consensus-based framework for conducting and reporting osteoarthritis phenotype research

  • van Spil, W. E.1
  • Bierma-Zeinstra, S. M. A.2, 2
  • Deveza, L. A.3
  • Arden, N. K.4, 3
  • Bay-Jensen, A.-C.5
  • Kraus, V. Byers6
  • Carlesso, L.7
  • Christensen, R.8, 9
  • Van Der Esch, M.10
  • Kent, P.11, 9
  • Knoop, J.12
  • Ladel, C.13
  • Little, C. B.3
  • Loeser, R. F.14
  • Losina, E.15
  • Mills, K.16
  • Mobasheri, A.17
  • Nelson, A. E.14
  • Neogi, T.18
  • Peat, G. M.19, 20
  • And 5 more
  • 1 University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands , Utrecht (Netherlands)
  • 2 Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands , Rotterdam (Netherlands)
  • 3 University of Sydney, Sydney, Australia , Sydney (Australia)
  • 4 University of Oxford, Oxford, UK , Oxford (United Kingdom)
  • 5 Nordic Bioscience, Herlev, Denmark , Herlev (Denmark)
  • 6 Duke University, Durham, USA , Durham (United States)
  • 7 Université de Montréal, Montréal, Canada , Montréal (Canada)
  • 8 The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, Denmark , Frederiksberg (Denmark)
  • 9 University of Southern Denmark, Odense, Denmark , Odense (Denmark)
  • 10 Reade, Center of Rehabilitation and Rheumatology, Amsterdam, The Netherlands , Amsterdam (Netherlands)
  • 11 Curtin University, Bentley, Australia , Bentley (Australia)
  • 12 VU Amsterdam, Amsterdam, The Netherlands , Amsterdam (Netherlands)
  • 13 Merck KGaA, Darmstadt, Germany , Darmstadt (Germany)
  • 14 University of North Carolina, Chapel Hill, NC, USA , Chapel Hill (United States)
  • 15 Brigham and Women’s Hospital, Boston, USA , Boston (United States)
  • 16 Macquarie University, Sydney, Australia , Sydney (Australia)
  • 17 University of Oulu, Oulu, Finland , Oulu (Finland)
  • 18 Boston University, Boston, USA , Boston (United States)
  • 19 Keele University, Staffordshire, UK , Staffordshire (United Kingdom)
  • 20 Haywood Academic Rheumatology Centre, Midlands Partnership NHS Foundation Trust, Haywood Hospital, Staffordshire, UK , Staffordshire (United Kingdom)
  • 21 Université de Lorraine, Nancy, EA 4360, France , Nancy (France)
  • 22 Glasgow Caledonian University, Glasgow, UK , Glasgow (United Kingdom)
  • 23 University of Nottingham, Nottingham, UK , Nottingham (United Kingdom)
Published Article
Arthritis Research & Therapy
Springer Science and Business Media LLC
Publication Date
Mar 20, 2020
DOI: 10.1186/s13075-020-2143-0
Springer Nature


BackgroundThe concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research.MethodsA panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies.ResultsFour Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided.ConclusionsThis study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.

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