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Consensus workshop on the toxic effects of long-term PUVA therapy.

Authors
  • Morison, W L1
  • Baughman, R D
  • Day, R M
  • Forbes, P D
  • Hoenigsmann, H
  • Krueger, G G
  • Lebwohl, M
  • Lew, R
  • Naldi, L
  • Parrish, J A
  • Piepkorn, M
  • Stern, R S
  • Weinstein, G D
  • Whitmore, S E
  • 1 Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
Type
Published Article
Journal
Archives of Dermatology
Publisher
American Medical Association
Publication Date
May 01, 1998
Volume
134
Issue
5
Pages
595–598
Identifiers
PMID: 9606329
Source
Medline
License
Unknown

Abstract

The possibility that there is an increased risk of melanoma in patients with psoriasis treated with psoralen-UV-A (PUVA) therapy has raised concern on the part of physicians and patients about the long-term safety of this treatment. In response to this concern, the National Psoriasis Foundation sponsored a workshop at which invited participants with expertise in PUVA therapy, psoriasis treatment, melanoma and nonmelanoma skin cancer, and epidemiological and clinical trials were asked to develop a consensus on the following 3 issues: the risk of long-term adverse effects of PUVA therapy with emphasis on nonmelanoma and melanoma skin cancer; the guidelines for physicians and patients for selection and use of PUVA therapy with consideration of the risk-benefit ratio of this treatment compared with the risk-benefit ratios of alternative treatments; and the directions for further evaluation of the long-term effects Of PUVA therapy.

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