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The connection between transcription and genomic instability.

Authors
  • Aguilera, Andrés1
  • 1 Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain. [email protected] , (Spain)
Type
Published Article
Journal
The EMBO journal
Publication Date
Feb 01, 2002
Volume
21
Issue
3
Pages
195–201
Identifiers
PMID: 11823412
Source
Medline
License
Unknown

Abstract

Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination. Not surprisingly, therefore, there is a physical and functional connection between these processes. In recent years, transcription has proven to be a relevant player in the maintenance of genome integrity and in the induction of genetic instability and diversity. The aim of this review is to provide an integrative view on how transcription can control different aspects of genomic integrity, by exploring different mechanisms that might be responsible for transcription-associated mutation (TAM) and transcription-associated recombination (TAR).

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