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Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.

Authors
  • Reese, Alexander1
  • Margo, Curtis Edward2
  • 1 Pathology and Cell Biology, USF Health Morsani College of Medicine, Tampa, Florida, USA.
  • 2 Pathology and Cell Biology, and Ophthalmology, Morsani College of Medicine, Tampa, Florida, USA [email protected]
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
May 01, 2022
Volume
75
Issue
5
Pages
354–358
Identifiers
DOI: 10.1136/jclinpath-2020-207302
PMID: 33619216
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Conjunctival squamous intraepithelial neoplasia (CSIN) represents the in situ precursor of squamous cell carcinoma. The graded severity of intraepithelial dysplasia is considered a measure of risk for progression to invasive carcinoma. The range of cytoarchitectural changes in CSIN overlaps those of reactive atypia, squamous epithelial papilloma and in situ sebaceous carcinoma. Pseudoepitheliomatous hyperplasia and benign hereditary dyskeratosis of the conjunctiva are conditions without risk of neoplastic transform that are potentially mistaken for CSIN. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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