Affordable Access

Publisher Website

Congenital Acute Myeloid Leukemia with Unique Translocation t(11;19)(q23;p13.3).

Authors
  • Yarbrough, Chester K1
  • Bandt, S Kathleen2
  • Hurth, Kyle3
  • Wambach, Jennifer A4
  • Rao, Rakesh4
  • Kulkarni, Shashikant5
  • White, Francis V5
  • Frater, John L5
  • Leonard, Jeffrey R6
  • 1 School of Medicine, Washington University School of Medicine.
  • 2 Neurological Surgery, Washington University School of Medicine.
  • 3 Pathology, Neuropathology, Keck School of Medicine of USC.
  • 4 Pediatrics, Newborn Medicine, Washington University School of Medicine.
  • 5 Pathology and Immunology, Washington University School of Medicine.
  • 6 Neurological Surgery, The Ohio State University, Nationwide Children's Hospital.
Type
Published Article
Journal
Cureus
Publisher
Cureus, Inc.
Publication Date
Jul 01, 2015
Volume
7
Issue
7
Identifiers
DOI: 10.7759/cureus.289
PMID: 26244121
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Congenital leukemia is rarely encountered in clinical practice, even in tertiary children's hospitals. Leukemia may cause significant coagulopathy, putting the patient at risk of intracranial hemorrhage. In this case, the authors present a female infant with a unique mixed phenotypic congenital acute myeloid leukemia showing mixed-lineage leukemia (MLL) rearrangement and severe coagulopathy resulting in a large subdural hematoma. Despite the fatal outcome in this case, neurosurgical treatment of patients with acute myeloid leukemia should be considered if coagulopathy and the clinical scenario allow.

Report this publication

Statistics

Seen <100 times