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Congenital acantholytic dyskeratotic epidermal naevus following Blaschko's lines versus segmental Darier's disease.

Authors
Type
Published Article
Journal
European journal of dermatology : EJD
Publication Date
Volume
17
Issue
2
Pages
130–132
Identifiers
PMID: 17337395
Source
Medline

Abstract

A Japanese newborn male with an unremarkable family history presented at birth with verrucous papules on the left side of the trunk and limbs, distributed along Blaschko's lines. Histological examination showed mild acantholytic dyskeratosis, consistent with Darier's disease; however, search for mutations of the SERCA gene, performed on DNA extracted from cells from involved and uninvolved skin and peripheral blood proved negative. The absence of detectable SERCA mutations did not allow confirmation of the diagnosis of (segmental) Darier's disease, and a tentative diagnosis of congenital acantholytic dyskeratotic epidermal nevus was considered. The relationship between the two conditions is briefly discussed.

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