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Recent developments in copper and zinc homeostasis in bacterial pathogens

Authors
  • Braymer, Joseph J
  • Giedroc, David P1
  • 1 Department of Chemistry, Indiana University
Type
Published Article
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Volume
19
Pages
59–66
Identifiers
DOI: 10.1093/nar/gkt902
Source
Elsevier
License
Unknown

Abstract

Copper and zinc homeostasis systems in pathogenic bacteria are required to resist host efforts to manipulate the availability and toxicity of these metal ions. Central to this microbial adaptive response is the involvement of metal-trafficking and metal-sensing proteins that ultimately exercise control of metal speciation in the cell. Cu-specific and Zn-specific metalloregulatory proteins regulate the transcription of metal-responsive genes while metallochaperones and related proteins ensure that these metals are appropriately buffered by the intracellular milieu and delivered to correct intracellular targets. In this review, we summarize recent findings on how bacterial pathogens mount a metal-specific response to derail host efforts to win the ‘fight over metals.’

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