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Conflict of interest disclosure in biomedical research: a review of current practices, biases, and the role of public registries in improving transparency

Authors
  • Dunn, Adam G.1
  • Coiera, Enrico1
  • Mandl, Kenneth D.2, 3, 4
  • Bourgeois, Florence T.2, 3
  • 1 Macquarie University, Centre for Health Informatics, Australian Institute of Health Innovation, Sydney, NSW 2109, Australia , Sydney (Australia)
  • 2 Harvard Medical School, Department of Pediatrics, Boston, MA, 02115, USA , Boston (United States)
  • 3 Boston Children’s Hospital, Computational Health Informatics Program, Boston, MA, 02115, USA , Boston (United States)
  • 4 Harvard Medical School, Department of Biomedical Informatics, Boston, MA, 02115, USA , Boston (United States)
Type
Published Article
Journal
Research Integrity and Peer Review
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 03, 2016
Volume
1
Issue
1
Identifiers
DOI: 10.1186/s41073-016-0006-7
Source
Springer Nature
Keywords
License
Green

Abstract

Conflicts of interest held by researchers remain a focus of attention in clinical research. Biases related to these relationships have the potential to directly impact the quality of healthcare by influencing decision-making, yet conflicts of interest remain underreported, inconsistently described, and difficult to access. Initiatives aimed at improving the disclosure of researcher conflicts of interest are still in their infancy but represent a vital reform that must be addressed before potential biases associated with conflicts of interest can be mitigated and trust in the impartiality of clinical evidence restored. In this review, we examine the prevalence of conflicts of interest, evidence of the effects that disclosed and undisclosed conflicts of interest have had on the reporting of clinical evidence, and the emerging approaches for improving the completeness and consistency of disclosures. Through this review of emerging technologies, we recognize a growing interest in publicly accessible registries for researcher conflicts of interest and propose five desiderata aimed at maximizing the value of such registries: mandates for ensuring that researchers keep their records up to date; transparent records that are made available to the public; interoperability to allow researchers, bibliographic databases, and institutions to interact with the registry; a consistent taxonomy for describing different classes of conflicts of interest; and the ability to automatically generate conflicts of interest statements for use in published articles.

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