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The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure.

Authors
  • He, Sheng1
  • Wu, Jun2
  • Li, Shu-Hong2
  • Wang, Li3
  • Sun, Yu3
  • Xie, Jun4
  • Ramnath, Daniel2
  • Weisel, Richard D5
  • Yau, Terrence M6
  • Sung, Hsing-Wen7
  • Li, Ren-Ke8
  • 1 Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan, China. , (Canada)
  • 2 Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. , (Canada)
  • 3 Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 4 Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan, China. , (China)
  • 5 Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Cardiovascular Surgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada. , (Canada)
  • 6 Division of Cardiovascular Surgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada. , (Canada)
  • 7 Department of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan, ROC. , (Taiwan)
  • 8 Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Cardiovascular Surgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Biomaterials
Publication Date
Aug 03, 2020
Volume
258
Pages
120285–120285
Identifiers
DOI: 10.1016/j.biomaterials.2020.120285
PMID: 32781327
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Myocardial fibrosis, resulting from ischemic injury, increases tissue resistivity in the infarct area, which impedes heart synchronous electrical propagation. The uneven conduction between myocardium and fibrotic tissue leads to dys-synchronous contraction, which progresses towards ventricular dysfunction. We synthesized a conductive poly-pyrrole-chitosan hydrogel (PPY-CHI), and investigated its capabilities in improving electrical propagation in fibrotic tissue, as well as resynchronizing cardiac contraction to preserve cardiac function. In an in vitro fibrotic scar model, conductivity increased in proportion to the amount of PPY-CHI hydrogel added. To elucidate the mechanism of interaction between myocardial ionic changes and electrical current, an equivalent circuit model was used, which showed that PPY-CHI resistance was 10 times lower, and latency time 5 times shorter, compared to controls. Using a rat myocardial infarction (MI) model, PPY-CHI was injected into fibrotic tissue 7 days post MI. There, PPY-CHI reduced tissue resistance by 30%, improved electrical conduction across the fibrotic scar by 33%, enhanced field potential amplitudes by 2 times, and resynchronized cardiac contraction. PPY-CHI hydrogel also preserved cardiac function at 3 months, and reduced susceptibility to arrhythmia by 30% post-MI. These data demonstrated that the conductive PPY-CHI hydrogel reduced fibrotic scar resistivity, and enhanced electrical conduction, to synchronize cardiac contraction. Copyright © 2020 Elsevier Ltd. All rights reserved.

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