The conduct of phase I-II clinical trials in children with cancer.
- Published Article
Medical and pediatric oncology
- Publication Date
Jan 01, 1991
Phase I Clinical Trials in children with cancer are carried out with therapeutic intent, so as to define antileukemic/antitumor activity, dose-limiting toxicity, maximum tolerated dosage, and pharmacokinetics. These studies define a dosage of an agent or combination that may be used in a larger study of pediatric patients with leukemias or malignant solid tumors. The content of phase I and II protocols is outlined, with a brief discussion of the ethics of performance of phase I trials in children.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2056975