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Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

Authors
  • Iserman, Christiane1
  • Desroches Altamirano, Christine1, 2
  • Jegers, Ceciel1
  • Friedrich, Ulrike3
  • Zarin, Taraneh4
  • Fritsch, Anatol W.1, 5
  • Mittasch, Matthäus1, 5
  • Domingues, Antonio1, 5
  • Hersemann, Lena1, 5
  • Jahnel, Marcus1, 2
  • Richter, Doris1, 2
  • Guenther, Ulf-Peter6
  • Hentze, Matthias W.7
  • Moses, Alan M.4, 8
  • Hyman, Anthony A.1
  • Kramer, Günter3
  • Kreysing, Moritz1, 5
  • Franzmann, Titus M.1, 2
  • Alberti, Simon1, 2
  • 1 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
  • 2 BIOTEC and CMCB, Technische Universität Dresden, Tatzberg 47/48, 01307 Dresden, Germany
  • 3 ance, 69120 Heidelberg, Germany
  • 4 Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
  • 5 Center for Systems Biology Dresden, 01307 Dresden, Germany
  • 6 DKMS Life Science Lab GmbH, St. Petersburger Str. 2, 01069 Dresden, Germany
  • 7 EMBL Heidelberg, Director’s Research Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany
  • 8 Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada
Type
Published Article
Journal
Cell
Publisher
Cell Press
Publication Date
May 14, 2020
Volume
181
Issue
4
Pages
818–831
Identifiers
DOI: 10.1016/j.cell.2020.04.009
PMID: 32359423
PMCID: PMC7237889
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Heat-induced phase separation of a helicase promotes a switch in translation from housekeeping transcripts to stress-response transcripts.

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