Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

Authors

• Iserman, Christiane¹
• Desroches Altamirano, Christine^{1, 2}
• Jegers, Ceciel¹
• Friedrich, Ulrike³
• Zarin, Taraneh⁴
• Fritsch, Anatol W.^{1, 5}
• Mittasch, Matthäus^{1, 5}
• Domingues, Antonio^{1, 5}
• Hersemann, Lena^{1, 5}
• Jahnel, Marcus^{1, 2}
• Richter, Doris^{1, 2}
• Guenther, Ulf-Peter⁶
• Hentze, Matthias W.⁷
• Moses, Alan M.^{4, 8}
• Hyman, Anthony A.¹
• Kramer, Günter³
• Kreysing, Moritz^{1, 5}
• Franzmann, Titus M.^{1, 2}
• Alberti, Simon^{1, 2}

• ¹ Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
• ² BIOTEC and CMCB, Technische Universität Dresden, Tatzberg 47/48, 01307 Dresden, Germany
• ³ ance, 69120 Heidelberg, Germany
• ⁴ Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
• ⁵ Center for Systems Biology Dresden, 01307 Dresden, Germany
• ⁶ DKMS Life Science Lab GmbH, St. Petersburger Str. 2, 01069 Dresden, Germany
• ⁷ EMBL Heidelberg, Director’s Research Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany
• ⁸ Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada

Type

Published Article

Journal

Cell

Publisher

Cell Press

Publication Date

May 14, 2020

Volume

181

Issue

4

Pages

818–831

Identifiers

DOI: 10.1016/j.cell.2020.04.009

PMID: 32359423

PMCID: PMC7237889

Source

PubMed Central

Keywords

• Phase Separation
• Heat Stress
• Evolutionary Adaptation
• Heat Shock Response
• 5′
• Utr
• Ribosomal Scanning
• Ded1P
• Condensate
• Chaperone
• Cytosolic Ph

Disciplines

• Article

License

Unknown