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Concordance between two rapid diagnostic tests for the detection of antibodies against SARS-CoV-2

Authors
  • de la Iglesia, Jaime1
  • Fernández-Villa, Tania2
  • Fegeneda-Grandes, Juan M.3
  • Gómez-García, Manuel3
  • Majo García, Raúl4
  • López Sanz, Silvia5
  • Mendez da Cuña, Patricia6
  • Llaneza García, Marta7
  • Marcos Sádaba, Alicia8
  • Fernández Vázquez, José Pedro9
  • 1 Especialista en Medicina Familiar y Comunitaria. Centro de salud Condesa, León
  • 2 Grupo de investigación en Interacciones Gen-Ambiente y Salud (GIIGAS) / Instituto de Biomedicina (IBIOMED). Universidad de León, León
  • 3 Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León
  • 4 Centro de Salud Eras de Renueva, Gerencia de Atención Primaria del Área de Salud de León, León
  • 5 Centro de salud Ribera del Esla, Gerencia de Atención Primaria del Área de Salud de León, León
  • 6 Residente de tercer año de Medicina familiar y Comunitaria. Centro de salud La Palomera, León
  • 7 Residente de segundo año de Medicina familiar y Comunitaria. Centro de salud Trobajo del Camino, León
  • 8 Residente de primer año de Medicina familiar y Comunitaria. Centro de salud Eras de Renueva, León
  • 9 Gerencia de Atención Primaria del Área de Salud de León, León
Type
Published Article
Journal
Semergen
Publisher
Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Published by Elsevier España, S.L.U.
Publication Date
Jun 17, 2020
Volume
46
Pages
21–25
Identifiers
DOI: 10.1016/j.semerg.2020.06.009
PMID: 32675000
PMCID: PMC7298458
Source
PubMed Central
Keywords
License
Unknown

Abstract

Objective To assess the agreement between two rapid detection tests (RDT) for antibodies against SARS-CoV-2 infection. Materials and methods This was a cross-sectional study that used a random sample of non-hospitalized patients from the primary care management division of the Healthcare Area of Leon (58 RT-PCR-positive cases and 52 RT-PCR-negative cases). Information regarding symptoms was collected and all patients were simultaneously tested using two RDTs (Combined - cRDT and Differentiated - dRDT). The results of both tests were evaluated using the chi-square test and, for degree of agreement, the kappa coefficient. Results About 52% of the participants were women (mean age: 48.2 ± 11.0 years). A total of 58.2% were positive for d-RDT and 41.2% were positive for c-RDT. In the subjects who were RT-PCR-positive, d-RDT was positive in 72.4% and c-RDT in 55.2%; in those who were RT-PCR-negative, the percentages were 42.3% and 26.9%, respectively. The kappa coefficient observed between the two RDTs was 0.644, and was higher in patients without a fever or anosmia (0.725) and lower in those with a fever or anosmia (0.524). Conclusions There is good agreement between the tests used in this study. Given the sensitivity observed, they can be very useful as a complement to RT-PCR.

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