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Concomitant reduction of matrix metalloproteinase-2 secretion and intracellular reactive oxygen species following anti-sense inhibition of telomerase activity in PC-3 prostate carcinoma cells.

Authors
  • Shariftabrizi, Ahmad
  • Khorramizadeh, Mohammad Reza
  • Saadat, Farshid
  • Alimoghadam, Kamran
  • Safavifar, Farnaz
  • Ebrahimkhani, Mohammad Reza
Type
Published Article
Journal
Molecular and cellular biochemistry
Publication Date
May 01, 2005
Volume
273
Issue
1-2
Pages
109–116
Identifiers
PMID: 16013445
Source
Medline
License
Unknown

Abstract

Concomitant reduction of the pro-MMP-2 secretion and ROS in PC-3 cells following hTR inhibition suggests that over-activity of telomerase in cancer cells might increase the level of matrix metalloproteinase-2 and thus, be directly involved in the invasion process through enhancement of intracellular oxidative stress.

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