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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Authors
  • Alexander, Stephen Ph1
  • Kelly, Eamonn2
  • Marrion, Neil V2
  • Peters, John A3
  • Faccenda, Elena4
  • Harding, Simon D4
  • Pawson, Adam J4
  • Sharman, Joanna L4
  • Southan, Christopher4
  • Buneman, O Peter5
  • Cidlowski, John A6
  • Christopoulos, Arthur7
  • Davenport, Anthony P8
  • Fabbro, Doriano9
  • Spedding, Michael10
  • Striessnig, Jörg11
  • Davies, Jamie A4
  • 1 School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
  • 2 School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
  • 3 Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  • 4 Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
  • 5 Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, United Kingdom. , (United Kingdom)
  • 6 National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • 7 Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria 3052, Australia. , (Australia)
  • 8 Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • 9 PIQUR Therapeutics, Basel, 4057, Switzerland. , (Switzerland)
  • 10 Spedding Research Solutions SARL, Le Vésinet, 78110, France. , (France)
  • 11 Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria. , (Austria)
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2017
Volume
174 Suppl 1
Identifiers
DOI: 10.1111/bph.13882
PMID: 29055037
Source
Medline
License
Unknown

Abstract

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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