Affordable Access

deepdyve-link
Publisher Website

A concise and diversity-oriented approach to the synthesis of SAG derivatives.

Authors
  • Wang, Nengdong
  • Xiang, Jing
  • Ma, Zhibo
  • Quan, Junmin
  • Chen, Jiahua
  • Yang, Zhen
Type
Published Article
Journal
Journal of Combinatorial Chemistry
Publisher
American Chemical Society
Publication Date
Jan 01, 2008
Volume
10
Issue
6
Pages
825–834
Identifiers
DOI: 10.1021/cc800025n
PMID: 18754644
Source
Medline
License
Unknown

Abstract

An efficient and rapid solution-phase combinatorial synthesis of the SAG library was developed. The salient features for this library synthesis is the application of carbothioamide-derived palladacycle-catalyzed Suzuki coupling reactions for the parallel synthesis of a series of pyridine-based biaryl aldehydes under aerobic conditions and a direct N-alkylation of carbamates using NaH as base in DMF in the presence of catalytic amount of water. The resultant library has been submitted to biological screening to evaluate their potential role in the regulation of Hedgehog pathway.

Report this publication

Statistics

Seen <100 times